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Universität Bielefeld > Fakultät für Chemie > Arbeitsgruppen > Strukturbiochemie

Publikationen von Prof. Dr. Hartmut Niemann

Begutachtete Originalbeiträge

Buss M, Geerds C, Patschkowski T, Niehaus K, Niemann HH (2018)
Perfect merohedral twinning combined with noncrystallographic symmetry potentially causes the failure of molecular replacement with low-homology search models for the flavin-dependent halogenase HalX from Xanthomonas campestris.
Acta Crystallogr F Struct Biol Commun, 74, 351-354
PDF Reprint

Neubauer PR, Widmann C, Wibberg D, Schröder L, Frese M, Kottke T, Kalinowski J, Niemann HH, Sewald N. (2018)
A flavin-dependent halogenase from metagenomic analysis prefers bromination over chlorination.
PLoS One 13, e0196797

Harwardt MIE, Young P, Bleymüller WM, Meyer T, Karathanasis C, Niemann HH, Heilemann M, Dietz MS. (2017)
Membrane dynamics of resting and internalin B-bound MET receptor tyrosine kinase studied by single-molecule tracking.
FEBS Open Bio. 7, 1422-1440

Bleymüller WM, Lämmermann, N, Ebbes M, Maynard D, Geerds C, Niemann HH (2016)
MET-activating Residues in the B-repeat of the Listeria monocytogenes Invasion Protein InlB.
J. Biol. Chem. 291, 25567-25577

Schreiner M, Schlesinger R, Heberle J, Niemann HH (2016)
Crystal structure of Halobacterium salinarum halorhodopsin with a partially depopulated primary chloride-binding site
Acta Crystallogr F Struct Biol Commun, 72, 692-699
PDF Reprint

Koschut D, Richert L, Pace G, Niemann HH, Mély Y, Orian-Rousseau V (2016)
Live cell imaging shows hepatocyte growth factor-induced Met dimerization.
Biochim Biophys Acta.1863, 1552-1558

Volz Y, Koschut D, Matzke-Ogi A, Dietz MS, Karathanasis C, Richert L, Wagner MG, Mely Y, Heilemann M, Niemann HH, Orian-Rousseau V (2015)
Direct Binding of Hepatocyte Growth Factor and Vascular Endothelial Growth Factor to CD44v6
Biosci. Rep.35, e00236

Schreiner M, Schlesinger R, Heberle J, Niemann HH (2015)
Structure of Halorhodopsin from Halobacterium salinarum in a new crystal form that imposes little restraint on the E-F loop.
J. Struct. Biol. 190, 373-378

Barden S, Niemann HH (2015)
Adhesion of Several Cell Lines to Helicobacter pylori CagL is Mediated by Integrin αVβ6 via an RGDLXXL Motif
J. Mol. Biol. 427, 1304-1315

Geerds C, Wohlmann J, Haas A, Niemann HH (2014)
Structure of Rhodococcus equi virulence-associated protein B (VapB) reveals an eight-stranded antiparallel β-barrel consisting of two Greek-key motifs.
Acta Crystallogr. F Struct. Biol. Commun. 70, 866-871

Barden S, Schomburg B, Conradi J, Backert S, Sewald N, Niemann HH (2014)
Structure of a three-dimensional domain-swapped dimer of the Helicobacter pylori type IV secretion system pilus protein CagL.
Acta Crystallogr. D Biol. Crystallogr. 70, 1391-1400
PDF Reprint

Breitsprecher D, Gherardi E, Bleymüller WM, Niemann HH (2014)
Crystal structure of an engineered YopM-InlB hybrid protein.
BMC Struct. Biol. 14:12

Kolditz F, Krausze J, Heinz DW, Niemann HH, Müller-Goymann C (2014)
Wound Healing Potential of a Dimeric InlB Variant Analyzed by In Vitro Experiments on Re-epithelialization of Human Skin Models.
Eur. J. Pharm. Biopharm.86, 277-283

Dietz MS, Fricke F, Krüger C, Niemann HH, Heilemann M (2014)
Receptor-Ligand Interactions: Binding Affinities Studied by Single-Molecule and Super-Resolution Microscopy on Intact Cells.
Chemphyschem 15, 671-676

Barden S, Lange S, Tegtmeyer N, Conradi J, Sewald N, Backert S, Niemann HH (2013)
A Helical RGD Motif Promoting Cell Adhesion: Crystal Structures of the Helicobacter pylori Type IV Secretion System Pilus Protein CagL.
Structure 21, 1931-1941

Dietz MS, Haße D, Ferraris DM, Göhler A, Niemann HH, Heilemann M (2013)
Single-molecule photobleaching reveals increased MET receptor dimerization upon ligand binding in intact cells.
BMC Biophys. 6:6
Comment on this article in BMC Biophysics

Niemann HH, Gherardi E, Bleymüller WM, Heinz DW (2012)
Engineered variants of InlB with an additional leucine-rich repeat discriminate between physiologically relevant and packing contacts in crystal structures of the InlB:MET complex
Protein Sci. 21, 1528-1539
Editorial Highlight in Protein Science

Schreiner M, Niemann HH (2012)
Crystal structure of the Yersinia enterocolitica type III secretion chaperone SycD in complex with a peptide of the minor translocator YopD
BMC Struct. Biol. 12:13

Thoms S, Hofhuis J, Thöing C, Gärtner J, Niemann HH (2011)
The unusual extended C-terminal helix of the peroxisomal α/ϐ-hydrolase Lpx1 is involved in dimer contacts but dispensable for dimerization
J. Struct. Biol. 175, 362-371

Ebbes M, Bleymüller WM, Cernescu M, Nölker R, Brutschy B, Niemann HH (2011)
Fold and function of the InlB B-repeat.
J. Biol. Chem. 286, 15496-15506

Lutz J, Brabeck C, Niemann HH, Kloz U, Korth C, Lingappa VR, Bürkle A (2010)
Microdeletions within the hydrophobic core region of cellular prion protein alter its topology and metabolism
Biochem. Biophys. Res. Commun. 393, 439-444

Ferraris DM, Gherardi E, Di Y, Heinz DW, Niemann HH (2010)
Ligand-Mediated Dimerization of the Met Receptor Tyrosine Kinase by the Bacterial Invasion Protein InlB
J. Mol. Biol. 395, 522-532
Cover of Journal of Molecular Biology in January 2010
Postprint in the HZI Repositorium

Jung C, Matzke A, Niemann HH, Schwerk C, Tenenbaum T, Orian-Rousseau V (2009)
Involvement of CD44v6 in InlB-dependent Listeria invasion
Mol. Microbiol. 72, 1196-1207

Niemann HH, Petoukhov MV, Härtlein M, Moulin M, Gherardi E, Timmins P, Heinz DW, Svergun D (2008)
X-ray and neutron small-angle scattering analysis of the complex formed by the Met receptor and the Listeria monocytogenes invasion protein InlB
J. Mol. Biol. 377, 489-500
Postprint in the HZI Repositorium

Büttner CR, Sorg I, Cornelis GR, Heinz DW, Niemann HH (2008)
Structure of the Yersinia enterocolitica Type III Secretion Translocator Chaperone SycD
J. Mol. Biol. 375, 997-1012
PDF Postprint in the HZI Repositorium

Bosse T, Ehinger J, Czuchra A, Benesch S, Steffen A, Wu X, Schloen K, Niemann HH, Scita G, Stradal TE, Brakebusch C, Rottner K (2007)
Cdc42 and Phosphoinositide 3-Kinase Drive Rac-Mediated Actin Polymerization Downstream of c-Met in Distinct and Common Pathways
Mol. Cell. Biol. 27, 6615-6628
PDF Postprint in the HZI Repositorium

Niemann HH, Jäger V, Butler PJG, van den Heuvel J, Schmidt S, Ferraris D, Gherardi E, Heinz DW (2007)
Structure of the human receptor tyrosine kinase Met in complex with the Listeria invasion protein InlB
Cell 130, 235-246
PDF Postprint in the HZI Repositorium
Comments on this article in Cell and in Nature Reviews in Microbiology

Baumann F, Tolnay M, Brabeck C, Pahnke J, Kloz U, Niemann HH, Heikenwälder M, Rulicke T, Bürkle A, Aguzzi A (2007)
Lethal recessive myelin toxicity of prion protein lacking its central domain
EMBO J. 26, 538-547

Niemann HH, Schmoldt HU, Wentzel A, Kolmar H, Heinz DW (2006)
Barnase fusion as a tool to determine the crystal structure of the small disulfide-rich protein McoEeTI
J. Mol. Biol. 356, 1-8

Büttner, CR, Cornelis GR, Heinz, DW, Niemann HH (2005)
Crystal structure of Yersinia enterocolitica type III secretion chaperone SycT
Protein Sci. 14, 1993-2002
Cover of Protein Science in August 2005

Machner MP, Frese S, Schubert WD, Orian-Rousseau V, Gherardi E, Wehland J, Niemann HH,  Heinz DW (2003)
Aromatic amino acids at the surface of InlB are essential for host cell invasion by Listeria monocytogenes
Mol. Microbiol. 48, 1525-1536

Klockow B, Tichelaar W, Madden DR, Niemann HH, Akiba T, Hirose K, Manstein DJ (2002)
The dynamin A ring complex: molecular organization and nucleotide-dependent conformational changes
EMBO J. 21, 240-250

Niemann HH, Knetsch MLW, Scherer A, Manstein DJ, Kull FJ (2001)
Crystal structure of a dynamin GTPase domain in both nucleotide-free and GDP-bound forms
EMBO J. 20, 5813-5821

Dietzel S, Niemann H, Brückner B, Maurange C, Paro R (1999)
The nuclear distribution of Polycomb during Drosophila melanogaster development shown with a GFP fusion protein
Chromosoma 108, 83-94

Ramirez-Alvarado M, Blanco FJ, Niemann H, Serrano L (1997)
Role of β-turn residues in β-hairpin formation and stability in designed peptides
J. Mol. Biol. 273, 898-912

Maercker C, Harjes P, Neben M, Niemann H, Sianidis G, Lipps HJ (1997)
The formation of new nucleoli during macronuclear development of the hypotrichous ciliate Stylonychia lemnae visualized by in situ hybridization
Chromosome Res. 5, 333-335


Niemann HH (2013)
Structural basis of MET receptor dimerization by the bacterial invasion protein InlB and the HGF/SF splice variant NK1
Biochim. Biophys. Acta 1834, 2195-2204
Cover of BBA Proteins and Proteomics in October 2013

Niemann HH (2011)
Structural insights into Met receptor activation
Eur. J. Cell Biol. 90, 972-981

Niemann HH, Schubert WD, Heinz DW (2004)
Adhesins and invasins of pathogenic bacteria: a structural view
Microbes Infect. 6, 101-112

Nicht begutachtete Beiträge

Niemann HH, Jäger V, Butler PJG, van den Heuvel J, Schmidt S, Ferraris D, Gherardi E, Heinz DW (2007)
A bacterial key to host cell entry: Activation of the human receptor tyrosine kinase Met by a bacterial ligand
ESRF Highlights 2007, 60-61

Büttner CR, Cornelis GR, Heinz DW, Niemann HH (2005)
Crystal structure of Yersinia enterocolitica type III secretion chaperone SycT
BESSY Annual Report 2005, 417-418

Niemann H (2003)
Structural Characterization of dynamin GTPases
B.I.F. Futura 18, 208-212

Dietzel S, Niemann H, Paro R (1999)
Visualization of the development of Drosophila embryos with a polycomb-GFP fusionprotein
Movies on the CD-ROM "GFP in Motion", compiled by Ludin B, Matus A, Trends in Cell Biology 9
Movies in Quicktime format are available on the homepage of Steffen Dietzel.