apl. Prof. Dr. Torben Lübke
Uni von A-Z
Universität Bielefeld > Fakultät für Chemie > Startseite der Biochemie I > apl. Prof. Dr. Torben Lübke

Publication list Torben Lübke (Peer-review)

Original publications

30. Pan X, Wang Y, Lübke T, Hinek A, Pshezhetsky AV (2017) Mice, double deficient in lysosomal serine carboxypeptidases Scpep1 and Cathepsin A develop the hyperproliferation vesicular corneal dystrophy and hypertrophic skin thickenings. PLoS One 12(2) [epub ahead of print]

29. Dhamale OP, Lawrence R, Wiegmann EM, Shah BA, Al-Mafraji K, Lamanna WC, Lübke T, Dierks T, Boons GJ, Esko JD (2017) Arylsulfatase K is the lysosomal 2-Sulfoglucuronate sulfatase. ACS Chem Biol. [epub ahead of print]

28. Wolf H, Damme M, Stroobants S, D'Hooge R, Beck HC, Hermans-Borgmeyer I, Lüllmann-Rauch R, Dierks T, Lübke T (2016) A mouse model for fucosidosis recapitulates storage pathology and neurological features of the milder form of the human disease. Dis Model Mech. 9(9):1015-28

27. Kowalewski B, Lübke T, Kollmann K, Braulke T, Reinheckel T, Dierks T, Damme M (2014) Molecular characterization of arylsulfatase G: expression, processing, glycosylation, transport and activity. J Biol Chem. 289(40): 27992-8005

26. Pan X, Grigoryeva L, Seyrantepe V, Peng J, Kollmann K, Tremblay J, Lavoie JL, Hinek A, Lübke T, Pshezhetsky AV (2014) Serine carboxypeptidase Scpep1 and Cathepsin A play complementary roles in regulation of vasoconstriction via inactivation of endothelin-1. PLoS Genet. 10(2):e1004146

25. Kong XY, Nesset, CK, Damme M, Loberg EM, Lübke T, Maelen J, Andersson KB, Lorenzo PI, Roos N, GH Thoresen, Rustan AC, Kase ET, Eskild W (2014) Loss of lysosomal membrane protein NCU-G1 results in spontaneous liver fibrosis with accumulation of lipofuscin and iron in Kupffer cells. Dis Model Mech. 7(3):351-62

24. Wiegmann EM, Westendorf E, Kalus I, Pringle TH, Lübke T, Dierks T (2013) Arylsulfatase K, a Novel Lysosomal Sulfatase. J Biol Chem. 288(42):30019-28

23. Milz F, Harder A, Neuhaus P, Breitkreuz-Korff O, Walhorn V, Lübke T, Anselmetti D, Dierks T (2013) Cooperation of binding sites at the hydrophilic domain of cell-surface sulfatase Sulf1 allows for dynamic interaction of the enzyme with its substrate heparan sulfate. Biochim Biophys Acta 1830(11):5287-98

22. Kollmann K, Damme M, Markmann S, Morelle W, Schweizer M, Hermanns- Borgmeyer I, Röchert AK, Pohl S, Lübke T, Michalski JC, Käkelä R, Walkley SU, Braulke T (2012) Lysosomal dysfunction causes neurodegeneration in mucolipidosis II 'knock-in' mice. Brain 135 (Pt9):2661-2675

21. Kowalewski B, Lamanna WC, Lawrence R, Damme M, Stroobants S, Padva M, Kalus I, Frese MA, Lübke T, Lüllmann-Rauch R, D'Hooge R, Esko JD, Dierks T (2012) Arylsulfatase G inactivation causes loss of heparan sulfate 3-O-sulfataseactivity and mucopolysaccharidosis in mice. Proc Natl Acad Sci U S A. 109(26):10310-5

20. Makrypidi G, Damme M, Müller-Loennies S, Trusch M, Schmidt B, Schlüter H, Heeren J, Lübke T, Saftig P, Braulke T (2012) Mannose 6-dephosphorylation of lysosomal proteins mediated by acid phosphatases Acp2 and Acp5. Mol Cell Biol. 32(4):774-782

19. Savalas LR, Gasnier B, Damme M, Lübke T, Wrocklage C, Debacker C, Jezegou A, Reinheckel T, Hasilik A, Saftig P, Schröder BA (2011) "Disrupted in renal carcinoma 2" (DIRC2)- a novel transporter of the lysosomal membrane - is proteolytically processed by cathepsin L. Biochem J. 439(1):113-128

18. Damme M, Stroobants S, Walkley SU, Lüllmann-Rauch R, D'Hooge R, Fogh J, Saftig P, Lübke T, Blanz J (2011) Cerebellar alterations and gait defects as therapeutic outcome measures for enzyme replacement therapy in α- mannosidosis. J Neuropathol Exp Neurol. 70 (1):83-94

17. Rosner C, Kruse PH, Lübke T, Walter L (2010) Rhesus macaque MHC class I molecules show differential subcellular localizations. Immunogenetics. 62(3):149-58

16. Damme M, Morelle W, Schmidt B, Andersson C, Fogh J, Michalski JC, Lübke T (2010) Impaired lysosomal trimming of N-linked oligosaccharides leads to hyperglycosylation of native lysosomal proteins in mannosidosis mice. Mol. Cell. Biol. 30(1):273-83

15. Lakomek K, Dickmanns A, Kettwig M, Urlaub H, Ficner R, Lübke T (2009) Initial insight into the function of the lysosomal 66.3-kDa protein from mouse by means of X-ray crystallography. BMC Struct Biol. 9(1):56

14. Schieweck O, Damme M, Schröder B, Hasilik A, Schmidt B, Lübke T (2009) NCU-G1 is a highly glycosylated integral membrane protein of the lysosome. Biochem J. 422(1):83-90

13. Lakomek K, Dickmanns A, Müller U, Kollmann K, Deuschl F, Berndt A, Lübke T, Ficner R (2009) Crystallization and de novo sulphur SAD phasing of the lysosomal 66.3-kDa protein from mouse. Acta Crystallogr D Biol Crystallogr. 65(Pt 3):220-8

12. Kollmann K, Damme M, Deuschl F, Kahle J, D'Hooge R, Lüllmann-Rauch R, Lübke T (2009) Molecular characterization and gene disruption of Scpep1 in mice. FEBS J. 276(5):1356-69

11. Fedele AO, Filocamo M, Di Rocco M, Sersale G, Lübke T, di Natale P, Cosma MP, Ballabio A. (2007) Mutational analysis of the HGSNAT gene in Italian patients with mucopolysaccharidosis IIIC (Sanfilippo C syndrome). Hum Mutat. 28(5):523 Mutation in brief #959

10. Hellbusch CC, Sperandio M, Frommhold D, Yakubenia S, Wild MK, Popovici D, Vestweber D, Grone HJ, von Figura K, Lübke T, Korner C. (2007) Golgi GDP-fucose transporter-deficient mice mimic congenital disorder of glycosylation IIc/Leukocyte adhesion deficiency II. J Biol Chem. 282(14):10762-72

9. Deuschl F, Kollmann K, von Figura K, Lübke T. (2006) Molecular characterization of the hypothetical 66.3-kDa protein in mouse: Lysosomal targeting, glycosylation, processing and tissue distribution. FEBS Lett. 580(24):5747-52

8. Thiel C, Lübke T, Matthijs G, von Figura K, Korner C. (2006) Targeted disruption of the mouse phosphomannomutase 2 gene causes early embryonic lethality. Mol Cell Biol. 26(15):5615-20

7. Tiede S, Storch S, Lübke T, Henrissat B, Bargal R, Raas-Rothschild A, Braulke T (2005) Mucolipidosis II is caused by mutations in MGC4170 gene encoding the α/β GlcNac-1-phosphotransferase. Nat Med. 11(10):1109-12

6. Kollmann K, Mutenda KE, Balleininger M, Eckermann E, von Figura K, Schmidt B, Lübke, T (2005) Identification of novel lysosomal matrix proteins by proteome analysis. Proteomics. 5(15):3966-78

5. Hartmann D, de Strooper B, Serneels L, Craessaerts K, Herreman A, Annaert W, Umans L, Lübke T, Illert AL, von Figura K, Saftig P (2002) The disintegrin/ metalloprotease ADAM 10 is essential for Notch signalling but not for α- secretase activity in fibroblasts. Hum Mol Genet. 11: 2615-24

4. Hansske B, Thiel C, Lübke T, Hasilik M, Höning S, Peters V, Heidemann PH, Hoffmann GF, Berger EG, von Figura K, Körner C. (2002) Deficiency of UDP- galactose: N-acetylglucosamine β-1,4-galactosyltransferase I causes the congenital disorder of glycosylation type IId. J Clin Invest. 109(6):725-33

3. Lübke T, Marquardt T, Etzioni A, Hartmann E, von Figura K, Körner C. (2001) Complementation cloning identifies CDG-IIc (LAD II), a new type of Congenital Disorders of Glycosylation, as a GDP-fucose transporter deficiency. Nat Genet. 28(1):73-6

2. Anderson LA, McNairn E, Lübke T, Pau RN, Boxer DH. (2000) ModE- dependent molybdate regulation of the molybdenum cofactor operon moa in Escherichia coli. J Bacteriol. 182(24):7035-43

1. Lübke T, Marquardt T, von Figura K, Körner C. (1999) A new type of carbohydrate deficient glycoprotein syndrome due to a decreased import of GDP-fucose into the golgi. J Biol Chem. 274(37):25986-9

II. Review (Peer-review)

1. Lübke T, Lobel P, Sleat D. (2009) Proteomics of the lysosome. Biochim Biophys Acta 1793(4):625-35 (IF 4,37)2. Kollmann K, Pohl S, Marschner K, Encarnacao M, Sakwa I, Tiede S, Poorthuis BJ, Lübke T, Müller-Loennies S, Storch S, Braulke T (2010) Mannose phosphorylation in health and disease. Eur J Cell Biol. 89(1):117-23 (IF 3,63)

III. Books

1. "Lysosomal Proteome and Transcriptome" by Jobst Landgrebe and Torben Lübke in "Lysosomes" edited by Paul Saftig (2004); ISBN: 978-0-387-2556