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RESEARCH GROUP Computational Metagenomics > Research

sequencer, agar plates, samples and tablet — © Alexander Lauterbach

Research

Computational Metagenomics

Over 99% of the microbial species observed in nature cannot be grown in pure culture making them inaccessible to classical genomic studies. Metagenomics and single cell genomics are two approaches to study the microbial ‘dark matter’.

Metagenomic Sequencing

Metagenomics, the direct analysis of DNA from a whole environmental community, represents a strategy for discovering genes with diverse functionality. In the past, the identification of new genes with desired activities has relied primarily on relatively low-throughput function-based screening of environmental DNA clone libraries. Current sequencing technologies can generate more than 600 Gbp of sequence data in a single experiment, allowing sequence-based metagenomic discovery of complete genes or even genomes from environmental samples with moderate microbial species complexity.