Medizinische Fakul­tät OWL

Aus­ge­wähl­te Pu­bli­ka­tio­nen

Serotonin-​specific neu­rons dif­fe­ren­tia­ted from human iPSCs form dis­tinct sub­ty­pes with syn­ap­tic pro­te­in as­sem­bly.
C. Jansch , G.C. Zieg­ler, A. Fo­re­ro, S. Gredy, S. Wäld­chen, M.R. Vi­ta­le, E. Svi­rin, J.E.M. Zöl­ler, J. Wai­der, K. Gün­ther, F. Eden­ho­fer, M. Sauer, E. Wischmey­er, K.P. Lesch. J Neural Transm (2021). doi: 10.1007/s00702-​021-02303-5.

Globotriaosylceramide-​induced re­duc­tion of K Ca 1.1 chan­nel ac­ti­vi­ty and ac­ti­va­ti­on of the Notch1 si­gna­ling pa­thway in skin fi­bro­blasts of male Fabry pa­ti­ents with pain.
V. Ri­ckert, D. Kra­mer, A.L. Schu­bert, C. Som­mer, E. Wischmey­er, N. Üçeyler . Exp Neu­rol  (2020) 324:113134, doi: 10.1016

Chlo­ro­form is a po­tent ac­ti­va­tor of car­diac and neu­ro­nal Kir3 chan­nels.
S. Kol­lert, F. Dö­ring, U. Gergs U, E. Wischmey­er. Naun­yn Schmie­de­bergs Arch Phar­ma­col (2020) 393(4):573-​580. doi: 10.1007/s00210-​019-01751-x.

Func­tio­nal ana­ly­sis of a triplet de­le­ti­on in the gene en­co­ding the so­dium glu­co­se trans­por­ter 3, a po­ten­ti­al risk fac­tor for ADHD.
N. Schä­fer, M. Fried­rich, M.E. Jørgen­sen, S. Kol­lert, H. Ko­ep­sell, E. Wischmey­er, K.P. Lesch, D. Gei­ger, F. Dö­ring (2018). Plo­sO­ne 13(10):e0205109. doi: 10.1371.

Cha­rac­te­riza­ti­on of small fiber pa­tho­lo­gy in a mouse model of Fabry di­sea­se.
L. Hof­mann, D. Hose, A. Grieß­ham­mer, R. Blum, F. Dö­ring, S. Dib-​Hajj, S. Wax­man, C. Som­mer, E. Wischmey­er, N. Üçeyler (2018). eLife 7. pii: e39300. doi: 10.7554.

Ni­mo­di­pi­ne fos­ters re­mye­li­na­ti­on in a mouse model of mul­ti­ple scle­ro­sis and in­du­ces microglia-​specific apo­pto­sis.
A. Scham­pel, O.Vo­lo­vitch, T. Ko­eni­ger, C. Scholz, S. Jörg, R. Lin­ker, E. Wischmey­er, M. Wunsch, J. Hell, S. Ergün, S. Ku­er­ten (2017). Proc. Natl. Acad. Sci. USA. 2017 Apr 18, E3295-​E3304

Ac­ti­va­ti­on of TRESK chan­nels by the in­flamma­to­ry me­dia­tor lyso­phos­pha­ti­dic acid ba­lan­ces no­cicep­ti­ve si­gnal­ling.
S. Kol­lert, B. Dom­bert, F. Dö­ring, E. Wischmey­er (2015). Sci. Rep. 2015 (5),12548

Dis­tri­bu­ti­on and func­tion of so­dium chan­nel sub­ty­pes in human atri­al myo­car­di­um.
S.G. Kauf­mann, R.E. We­sa­ten­broek, A.H. Maass, V. Lange, A. Ren­ner, E. Wischmey­er, A. Bonz, J. Muck, G. Ertel, W.A. Cat­ter­all, T. Scheu­er, S.K. Maier (2013). J. Mol. Cell. Car­di­ol. (61),133-4

Ec­to­pic ex­pres­si­on of neu­ro­ge­nin 2 alone is suf­fi­ci­ent to in­du­ce dif­fe­ren­tia­ti­on of em­bryo­nic stem cells into ma­tu­re neu­rons.
E.C. Thoma, E. Wischmey­er, N. Offen, K. Mau­rus, A.L. Siren, M. Schartl, T.U. Wag­ner (2012). PLoS One (8), e386

He­te­ro­di­me­riza­ti­on of se­ro­to­nin re­cep­tors 5-​HT1A and 5-HT7 dif­fe­ren­ti­al­ly re­gu­la­tes re­cep­tor si­gnal­ling and traf­fi­cking.
U. Ren­ner, A. Zeug, A. Wo­eh­ler, M. Nie­bert, A. Ditya­tev, G. Ditya­te­va, N Gor­in­ski, D. Gu­s­e­va, D. Abdel-​Galil, M. Fröh­lich, F. Dö­ring, E. Wischmey­er, D.W. Rich­ter , E. Neher, E.G. Poni­mas­kin (2012). J. Cell. Sci. (125), 2486-​99

TRESK two-​pore-domain K chan­nels con­sti­tu­te a si­gni­fi­cant com­po­nent of back­ground po­t­as­si­um cur­r­ents in mu­ri­ne dor­sal root gan­gli­on neu­ro­nes.
T. Do­bler, A. Spring­auf, S. To­vor­nik, M. Weber, A. Schmitt, R. Sedl­mei­er, E. Wischmey­er, F. Dö­ring (2007). J. Phy­si­ol. 585 (3), 867-​879

Acute sup­pres­si­on of in­ward­ly rec­ti­fy­ing Kir2.1 chan­nels by di­rect ty­ro­si­ne ki­na­se phos­pho­ry­la­ti­on.
E. Wischmey­er, F. Dö­ring, A. Kar­schin (1998). J. Biol. Chem. 273 (51),34063-​34068

Kir2.4: a novel brain K+ in­ward rec­ti­fier pre­do­mi­nant­ly ex­pres­sed in motor neu­rons of cra­ni­al nerve nu­clei.
C. Tö­pert , F. Dö­ring, E. Wischmey­er, C. Kar­schin, J. Brock­haus, K. Ball­anyi, C. Derst, A. Kar­schin (1998). J. Neu­ro­sci. 18 (11), 4096-​4105

Sub­u­nit in­ter­ac­tions in the as­sem­bly of neu­ro­nal Kir 3.0 in­ward­ly rec­ti­fy­ing K+ chan­nels.
E. Wischmey­er, F. Dö­ring, E. Wischmey­er, A. Spau­schus, A. Kar­schin (1997). Mol. Cell. Neu­ro­sci. 8, 1-14

Re­cep­tor sti­mu­la­ti­on cau­ses slow in­hi­bi­ti­on of IRK1 in­ward­ly rec­ti­fy­ing K+ chan­nels by di­rect pro­te­in ki­na­se A-​mediated phos­pho­ry­la­ti­on.
E. Wischmey­er, A. Kar­schin (1996). P. Natl. Acad. Sci. USA 93, 5819-​5823

 

 

Wei­te­re Pu­bli­ka­tio­nen

Tumor Sup­pres­sor Role of INPP4B in Che­mo­re­sistant Re­ti­nob­las­to­ma.
Mi­ro­sch­ni­kov N, Drä­ger O, Van Mee­nen D, Metz K, Bu­de­us B, Dün­ker N, Busch MA. J Oncol. 2023 Mar 8;2023:2270097. doi: 10.1155/2023/2270097. PMID: 36993823; PMCID: PMC10042642.

ADAM10 and ADAM17-​Novel Play­ers in Re­ti­nob­las­to­ma Car­ci­no­ge­ne­sis.
Van Mee­nen D, Doege A, Al­e­feld E, Haase A, Beier M, Kie­fer T, Bie­wald E, Metz K, Drä­ger O, Busch MA, Dün­ker N. Int J Mol Sci. 2022 Oct 20;23(20):12621. doi: 10.3390/ijms232012621. PMID: 36293469; PMCID: PMC9604041.

The De­mi­nish­ment of Novel En­do­me­tri­al Carcinoma-​Derived Stem-​like Cells by Tar­ge­ting Mi­to­chon­dri­al Bio­en­er­ge­tics and MYC.
Hel­weg LP, Wind­m­öl­ler BA, Burg­hardt L, Storm J, Förs­ter C, We­th­kamp N, Wil­kens L, Kalt­schmidt B, Banz-​Jansen C, Kalt­schmidt C. Int J Mol Sci. 2022 Feb 22;23(5):2426. doi: 10.3390/ijms23052426 . PMID: 35269569 ; PMCID: PMC8910063.

Inter-​ and In­tra­po­pu­la­tio­nal He­te­ro­gen­ei­ty of Cha­rac­te­ris­tic Mar­kers in Adult Human Neural Crest-​derived Stem Cells.
Wind­m­öl­ler BA, Hö­ving AL, Knab­be C, Grei­ner JFW. Stem Cell Rev Rep. 2022 Apr;18(4):1510-​1520. doi: 10.1007/s12015-​021-10277-w . Epub 2021 Nov 8. PMID: 34748196 ; PMCID: PMC9033708.