Medizinische Fakul­tät OWL

At­taai A, Nei­dert N, von Ehr A, Potru PS, Zöl­ler T, Spit­tau B. Post­na­tal ma­tu­ra­ti­on of mi­cro­glia is as­so­cia­ted with al­ter­na­ti­ve ac­ti­va­ti­on and ac­ti­va­ted TGFβ si­gna­ling. Glia. 2018 Aug;66(8):1695-​1708. doi: 10.1002/glia.23332. Epub 2018 Mar 25. PMID: 29575117.

Nei­dert N, von Ehr A, Zöl­ler T, Spit­tau B. Microglia-​Specific Ex­pres­si­on of Olfml3 Is Di­rect­ly Re­gu­la­ted by Trans­for­ming Growth Fac­tor β1-​Induced Smad2 Si­gna­ling. Front Im­mu­nol. 2018 Jul 26;9:1728. doi: 10.3389/fimmu.2018.01728. PMID: 30093905; PMCID: PMC6070609.

Spit­tau B, Do­ka­lis N, Prinz M. The Role of TGFβ Si­gna­ling in Mi­cro­glia Ma­tu­ra­ti­on and Ac­ti­va­ti­on. Trends Im­mu­nol. 2020 Jul 30:S1471-​4906(20)30152-​6. doi: 10.1016/j.it.2020.07.003. Epub ahead of print. PMID: 32741652.

Spit­tau B, Rilka J, Stein­f­ath E, Zöl­ler T, Kriegl­stein K. TGFβ1 in­crea­ses microglia-​mediated en­gul­f­ment of apo­pto­tic cells via up­re­gu­la­ti­on of the milk fat globule-​EGF fac­tor 8. Glia. 2015 Jan;63(1):142-​53. doi: 10.1002/glia.22740. Epub 2014 Aug 18. PMID: 25130376.

Spit­tau B, Wull­kopf L, Zhou X, Rilka J, Pfei­fer D, Kriegl­stein K. En­do­ge­nous trans­for­ming growth factor-​beta pro­mo­tes quie­scence of pri­ma­ry mi­cro­glia in vitro. Glia. 2013 Feb;61(2):287-​300. doi: 10.1002/glia.22435. Epub 2012 Oct 12. PMID: 23065670.

Spit­tau B. Aging Microglia-​Phenotypes, Func­tions and Im­pli­ca­ti­ons for Age- Re­la­ted Neu­ro­de­ge­ne­ra­ti­ve Di­sea­ses. Front Aging Neu­ro­sci. 2017 Jun 14;9:194. doi: 10.3389/fnagi.2017.00194. PMID: 28659790; PMCID: PMC5469878.

von Ehr A, At­taai A, Nei­dert N, Potru PS, Ruß T, Zöl­ler T, Spit­tau B. In­hi­bi­ti­on of Mi­cro­gli­al TGFβ Si­gna­ling In­crea­ses Ex­pres­si­on of Mrc1. Front Cell Neu­ro­sci. 2020 Mar 31;14:66. doi: 10.3389/fncel.2020.00066. PMID: 32296307; PMCID: PMC7137652.

Zhou X, Spit­tau B. Lipopolysaccharide-​Induced Mi­cro­glia Ac­ti­va­ti­on Pro­mo­tes the Sur­vi­val of Mid­brain Do­pa­miner­gic Neu­rons In Vitro. Neu­ro­tox Res. 2018 May;33(4):856-​867. doi: 10.1007/s12640-​017-9842-6. Epub 2017 Nov 29. PMID: 29188488.

Zhou X, Zöl­ler T, Kriegl­stein K, Spit­tau B. TGFβ1 in­hi­bits IFNγ-​mediated mi­cro­glia ac­ti­va­ti­on and pro­tects mDA neu­rons from IFNγ-​driven neu­ro­to­xi­ci­ty. J Neu­ro­chem. 2015 Jul;134(1):125-​34. doi: 10.1111/jnc.13111. Epub 2015 Apr 23. PMID: 25827682.

Zöl­ler T, At­taai A, Potru PS, Ruß T, Spit­tau B. Aged Mouse Cor­ti­cal Mi­cro­glia Dis­play an Ac­ti­va­ti­on Pro­fi­le Sug­ges­ting Im­mu­no­to­le­ro­ge­nic Func­tions. Int J Mol Sci. 2018 Mar 1;19(3):706. doi: 10.3390/ijms19030706. PMID: 29494550; PMCID: PMC5877567.

Zöl­ler T, Schnei­der A, Klei­mey­er C, Ma­su­da T, Potru PS, Pfei­fer D, Blank T, Prinz M, Spit­tau B. Si­len­cing of TGFβ si­gnal­ling in mi­cro­glia re­sults in im­pai­red ho­meo­sta­sis. Nat Com­mun. 2018 Oct 1;9(1):4011. doi: 10.1038/s41467-​018-06224-y. PMID: 30275444; PMCID: PMC6167353.