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  • Medizinische Fakul­tät OWL

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Publikationen

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Stand: August 2023

Ausgewählte Veröffentlichungen

Thévenod, F., Schreiber, T., Lee, W.K. (2022)
Renal hypoxia-HIF-PHD-EPO signaling in transition metal nephrotoxicity: friend or foe? Arch Toxicol (2022).

https://doi.org/10.1007/s00204-022-03285-3

Lee, W.K., Maass, M., Quach, A., Poscic, N., Prangley, H., Pallot, E.C., Kim, J.L., Pierce, J.S., Ogretmen, B., Futerman, A.H., Thévenod, F. (2021) Dependence of ABCB1 transporter expression and function on distinct sphingolipids generated by ceramide synthases-2 and -6 in chemoresistant renal cancer. J. Biol. Chem. 298: 101492.

https://doi.org/10.1016/j.jbc.2021.101492

Lee, W.K., Thévenod, F. (2020) Cell organelles as targets of mammalian cadmium toxicity. Arch. Toxicol. 94: 1017-1049.

https://doi.org/10.1007/s00204-020-02692-8

Lee, W.K., Thévenod, F. (2019) Oncogenic PITX2 Facilitates Tumor Cell Drug Resistance by Inverse Regulation of hOCT3/SLC22A3 and ABC Drug Transporters in Colon and Kidney Cancers. Cancer Lett. 449: 237-251.

https://doi.org/10.1016/j.canlet.2019.01.044

Lee, W.K., Kolesnick, R.N. (2017) Sphingolipid Abnormalities in Cancer Multidrug Resistance: Chicken or Egg? Cell. Signal. 38: 134-145.

https://doi.org/10.1016/j.cellsig.2017.06.017

Lee, W.K., Probst, S., Santoyo-Sanchez, M.P., Al-Hamdani, W., Diebels, I, von Sivers, J.K., Kerek, E., Prenner, E.J., Thévenod, F. (2017) Initial autophagic protection switches to disruption of autophagic flux by lysosomal instability during cadmium stress accrual in renal NRK-52E cells. Arch. Toxicol. 91: 3225-3245. equally contributing authors

https://doi.org/10.1007/s00204-017-1942-9

Nair, A.R., Lee, W.K., Smeets, K., Swennen, Q., Sanchez, A., Thévenod, F., Cuypers, A. (2015) Glutathione and mitochondria determine acute defense responses and adaptive processes in cadmium-induced oxidative stress and toxicity of the kidney. Arch. Toxicol. 89: 2273-89. equally contributing authors

https://doi.org/10.1007/s00204-014-1401-9

Dahdouh, F., Raane, M., Thévenod, F., Lee, W.K. (2014) Nickel-induced cell death and survival pathways in cultured renal proximal tubule cells: Roles of reactive oxygen species, ceramide and ABCB1. Arch. Toxicol. 88: 881-92.

https://doi.org/10.1007/s00204-014-1194-x

Lee, W.K., Chakraborty, P.K., Thévenod, F. (2013) Pituitary homeobox 2 (PITX2) protects renal cancer cell lines against doxorubicin toxicity by transcriptional activation of the multidrug transporter ABCB1. Int. J. Cancer 133: 556-67.

https://doi.org/10.1002/ijc.28060

Langelueddecke, C., Roussa, E., Fenton, R.A., Wolff, N.A., Lee, W.K., Thévenod, F. (2012) Lipocalin-2 (24p3/Neutrophil Gelatinase-associated Lipocalin (NGAL)) receptor is expressed in distal nephron and mediates protein endocytosis. J. Biol. Chem. 287: 159-169.

https://doi.org/10.1074/jbc.M111.308296

Lee, W.K., Chakraborty, P.K., Roussa, E., Wolff, N.A., Thévenod, F. (2012) ERK1/2-dependent bestrophin-3 expression prevents ER-stress-induced cell death of kidney proximal tubule cells by reducing CHOP. Biochim. Biophys. Acta – Mol. Cell Res. 1823: 1864-1876.

https://doi.org/10.1016/j.bbamcr.2012.06.003

Lee, W.K., Torchalski, B., Kohistani, N., Thévenod, F. (2011) ABCB1 protects kidney proximal tubule cells against cadmium-induced apoptosis: Roles of cadmium transport and ceramide metabolism. Toxicol. Sci. 121: 343-56.

https://doi.org/10.1093/toxsci/kfr071

Lee, W.K., Torchalski, B., Thévenod, F. (2007) Cadmium-induced ceramide formation triggers calpain-dependent apoptosis in cultured kidney proximal tubule cells. Am. J. Physiol. Cell Physiol. 293: C839-47.

https://doi.org/10.1152/ajpcell.00197.2007

Lee, W.K., Abouhamed, M., Thévenod, F. (2006) Caspase-dependent and –independent pathways for cadmium-induced apoptosis in cultured kidney proximal tubule cells. Am. J. Physiol. Renal Physiol. 291: F823-32.

https://doi.org/10.1152/ajprenal.00276.2005

Lee, W.K., Bork, U., Gholamrezaei, F., Thévenod, F. (2005) Cd2+-induced cytochrome c release in apoptotic proximal tubule cells: role of mitochondrial permeability transition pore and Ca2+ uniporter. Am. J. Physiol. Renal Physiol. 288: F27-39.

https://doi.org/10.1152/ajprenal.00224.2004

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