Medizinische Fakul­tät OWL

Aus­ge­wähl­te Pu­bli­ka­tio­nen (Pub­Med)

Ent­zünd­li­che Schmer­zen

Jonas R, Schmelz M. Sen­si­tiza­ti­on of supra-​threshold pain re­spon­ses—Trans­la­tio­nal aspects and me­cha­nisms. Front. Netw. Phy­si­ol., 2022. Sec. Sys­tems In­ter­ac­tions and Organ Net­works. https://doi.org/10.3389/fnetp.2022.1078890 (Re­view)

The­ken KN, Lee CR, Gong L, Caud­le KE, For­mea CM, Ga­edigk A, Klein TE, Agúndez JAG, Gros­ser T. Cli­ni­cal Phar­ma­co­ge­ne­tics Im­ple­men­ta­ti­on Con­sor­ti­um Gui­de­li­ne (CPIC) for CYP2C9 and Nons­te­ro­idal Anti-​Inflammatory Drugs. Clin Phar­ma­col Ther. 2020;108:191-​200. doi: 10.1002/cpt.1830.

The­ken KN, Hersh EV, La­hens NF, Lee HM, Li X, Gran­quist EJ, Gi­an­na­ko­pou­los HE, Levin LM, Se­cre­to SA, Grant GR, Detre JA, Fitz­Ge­rald GA, Gros­ser T*, Farrar JT*. Va­ria­bi­li­ty in the an­al­ge­sic re­spon­se to ibu­profen is as­so­cia­ted with cy­clooxy­ge­na­se ac­ti­va­ti­on in in­flamma­to­ry pain. Clin Phar­ma­col Ther. 2019;106:632-​641. doi: 10.1002/cpt.1446. [*) equal con­tri­bu­ti­on]

Gros­ser T, The­ken KN, Fitz­Ge­rald GA. Cy­clooxy­ge­na­se in­hi­bi­ti­on: Pain, in­flamma­ti­on, and the car­dio­va­s­cu­lar sys­tem. Clin Phar­ma­col Ther. 2017;102:611-​622. doi: 10.1002/cpt.794. (Re­view)

Gros­ser T, Woolf CJ, Fitz­Ge­rald GA. Time for no­n­ad­dic­ti­ve re­li­ef of pain. Sci­ence. 2017;355:1026-​1027. doi: 10.1126/sci­ence.aan0088. (Edi­to­ri­al)

Kar­dio­vas­ku­lä­res Sys­tem

Ka­the­ri­ne N. The­ken, So­u­mi­ta Ghosh, Cars­ten Skar­ke, Su­san­ne Fries, Ni­cho­las F. La­hens, Di­mi­tra Sa­ran­to­pou­lou, Gre­go­ry R. Grant, Gar­ret A. Fitz­Ge­rald, Tilo Gros­ser
De­gree of Cyclooxygenase-​2 In­hi­bi­ti­on Mo­du­la­tes Blood Pres­su­re Re­spon­se to Cele­coxib and Na­pro­xen.
me­dRxiv 2024.05.30.24308244; doi: https://doi.org/10.1101/2024.05.30.24308244
https://www.me­drxiv.org/con­tent/10.1101/2024.05.30.24308244v1

Tang SY, Lor­dan R, Meng H, Au­er­bach BJ, Hen­nes­sy EJ, Sen­gupta A, Das US, Joshi R, Marcos-​Contreras OA, Mc­Con­nell R, Grant GR, Ric­ciotti E, Mu­zy­kan­tov VR, Gros­ser T, Weil­jie AM, Fitz­Ge­rald GA.
Dif­fe­ren­ti­al Im­pact In Vivo of Pf4-ΔCre-​Mediated and Gp1ba-​ΔCre-​Mediated De­ple­ti­on of Cyclooxygenase-​1 in Plate­lets in Mice.
Ar­te­rios­cler Thromb Vasc Biol. 2024 Jun;44(6):1393-​1406.
doi: 10.1161/ATVBA­HA.123.320295. Epub 2024 Apr 25. PMID: 38660804; PMCID: PMC11138953. https://www.aha­jour­nals.org/doi/10.1161/ATVBA­HA.123.320295

Li X, Fries S, Li R, Law­son JA, Pro­pert KJ, Dia­mond SL, Blair IA, Fitz­Ge­rald GA, Gros­ser T. Dif­fe­ren­ti­al im­pair­ment of aspirin-​dependent plate­let cy­clooxy­ge­na­se ace­tyla­ti­on by nons­te­ro­idal an­ti­in­flamma­to­ry drugs. Proc Natl Acad Sci U S A. 2014;111:16830-​5. doi: 10.1073/pnas.1406997111.

Gros­ser T*, Fries S*, Law­son JA, Ka­poor SC, Grant GR, Fitz­Ge­rald GA. Drug re­sis­tance and pseu­do­re­sis­tance: an un­in­ten­ded con­se­quence of en­te­ric coa­ting aspi­rin. Cir­cu­la­ti­on. 2013;127(3):377-​85. doi: 10.1161/CIR­CU­LA­TIO­NA­HA.112.117283. [*) equal con­tri­bu­ti­on]

Fries S*, Gros­ser T*, Price TS, Law­son JA, Ka­poor S, De­Mar­co S, Plet­cher MT, Wilt­shire T, Fitz­Ge­rald GA. Mar­ked in­ter­in­di­vi­du­al va­ria­bi­li­ty in the re­spon­se to selec­ti­ve in­hi­bi­tors of cyclooxygenase-​2. Gas­tro­en­te­ro­lo­gy. 2006;130:55-64. doi: 10.1053/j.gas­tro.2005.10.002. PMID: 16401468. [*) equal con­tri­bu­ti­on]

Gros­ser T, Fries S, Fitz­Ge­rald GA. Bio­lo­gi­cal basis for the car­dio­va­s­cu­lar con­se­quen­ces of COX-2 in­hi­bi­ti­on: the­ra­peu­tic chal­len­ges and op­por­tu­nities. J Clin In­vest. 2006;116:4-15. doi: 10.1172/JCI27291. (Re­view)

COVID-​19

Lor­dan R, Prior S, Hen­nes­sy E, Naik A, Ghosh S, Pa­schos GK, Skar­ke C, Ba­re­kat K, Hol­lings­worth T, Juska S, Maza­l­eus­ka­ya LL, Tee­gar­den S, Glas­cock AL, An­der­son S, Meng H, Tang SY, Wel­jie A, Bot­ta­li­co L, Ric­ciotti E, Cher­fa­ne P, Mrce­la A, Grant G, Poole K, Mayer N, Wa­ring M, Adang L, Be­cker J, Fries S, Fitz­Ge­rald GA, Gros­ser T. Con­side­ra­ti­ons for the safe ope­ra­ti­on of schools du­ring the co­ro­na­vi­rus pan­de­mic. Front Pu­blic Health. 2021;9:751451. doi: 10.3389/fpubh.2021.751451. (Re­view)

Lor­dan R, Fitz­Ge­rald GA, Gros­ser T. Reo­pe­ning schools du­ring COVID-​19. Sci­ence. 2020;369:1146. doi: 10.1126/sci­ence.abe5765. (Edi­to­ri­al)